Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats

Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats

Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid...

Tumor incidence in normal Sprague-Dawley female rats.

Keishibukuryogan is not carcinogenic in Sprague-Dawley rats

Keishibukuryogan is a traditional Japanese medicine widely administered to patients with menopausal symptoms. Because humans use it on a long-term basis, we believed that a carcinogenicity study was warranted. We orally administered keishibukuryogan (TJ-25) extract powder to 6-week-old Sprague-Dawley rats [Crl:CD(SD)], which were divided into four dosage groups-0 (water for injection), 100, 500...

Responses in gut microbiota and fat metabolism to a halogenated methane analogue in Sprague Dawley rats

Recent studies on germ-free mice show that intestinal methanogens may be closely associated with host's adipose metabolism. The present study aimed to investigate effects of inhibition of intestinal methanogen populations on host fat metabolism by establishing a healthy Sprague Dawley (SD) rat model through the intragastric administration of bromochlordomethane (BCM). Forty-five 8-week old heal...

Adrenocortical response to 17-beta estradiol replacement in oophorectomized female sprague dawley rats.

OBJECTIVE To determine the effect of estradiol treatment on serum corticosterone levels in Oophorectomized (OVX) female Sprague Dawley rats exposed to chronic restraint stress. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Department of Physiology, Army Medical College, Rawalpindi and National Institute of Health, Islamabad, from January to December 2008. METHODOLOGY A tota...